Chemoprevention of cervical cancer with folic acid: a phase III Southwest Oncology Group Intergroup study.

The Effect of Folic Acid-Conjugated Coated Iron Oxide Nanoparticles in The Radiosensitization of Human Cervical Carcinoma Cell Line at Clinical Electron energies (6MeV)

Background and Purpose: The objective of this study was to investigate the therapeutic effect of Folic Acid-Conjugated polyglycerol coated iron oxide nanoparticles on the radiosensitivity of HeLa cells when irradiated with 6 MeV electron beams. Materials and Methods: Different concentrations of iron oxide nanoparticles (PG-SPIONs and FA-PG-SPIONs (25, 50, 100, 200 µg ml-1)) were synthesized by...

Biomarkers and their use in cervical cancer chemoprevention.

Cervical cancer chemoprevention agents under study include diet and micronutrients (particularly beta-carotene, folate, and vitamins A, C, and E); medications such as retinoids (retinyl acetate gel, all-trans-retinoic acid, and 4-hydroxyphenylretinamide) that are chemically related to micronutrients; and other chemopreventives meant to affect the carcinogenic process at the cellular level, incl...

Folic acid-modified diatrizoic acid-linked dendrimer-entrapped gold nanoparticles as nanoprobes for targeted CT imaging of human cervical cancer

American Society of Preventive Oncology Distinguished Career Achievement Lecture 2006--Enjoy the journey: the long and winding road of chemoprevention agent development.

My career in chemoprevention derived from an attempt to find a better treatment for cutaneous malignant melanoma (1). This led me to the exploration of retinoids as therapeutic modalities in a number of malignant conditions with the identification of activity in several epithelial malignancies (2-5), particularly squamous cell carcinoma and preneoplastic lesions of the skin (3, 4), as well as i...

Final results of phase III trial in regionally advanced unresectable non-small cell lung cancer: Radiation Therapy Oncology Group, Eastern Cooperative Oncology Group, and Southwest Oncology Group.

STUDY OBJECTIVES The purpose of this phase III clinical trial was to test whether chemotherapy followed by radiation therapy resulted in superior survival to either hyperfractionated radiation or standard radiation in surgically unresectable non-small cell lung cancer. DESIGN Patients were prospectively randomized to 2 months of cisplatin, vinblastine chemotherapy followed by 60 Gy of radiati...